Oral versus Intravenous Antibiotics for Bone and Joint Infection
نویسندگان
چکیده
منابع مشابه
Oral versus intravenous antibiotics in treatment of paediatric febrile neutropenia.
The purpose of this study is to determine whether, in low-risk febrile neutropenic paediatric populations, oral antibiotics are as effective as intravenous antibiotics in obtaining resolution of the febrile neutropenic episode. A comprehensive literature search of MEDLINE, EMBASE and CENTRAL identified prospective, randomised controlled trials comparing oral antibiotics with intravenous antibio...
متن کاملOral versus intravenous antibiotic treatment for bone and joint infections (OVIVA): study protocol for a randomised controlled trial
BACKGROUND Bone and joint infection in adults arises most commonly as a complication of joint replacement surgery, fracture fixation and diabetic foot infection. The associated morbidity can be devastating to patients and costs the National Health Service an estimated £20,000 to £40,000 per patient. Current standard of care in most UK centres includes a prolonged course (4-6 weeks) of intraveno...
متن کاملPaediatric bone and joint infection
Despite advances in understanding and management, paediatric osteoarticular infections continue to pose diagnostic difficulties for clinicians. Delays in diagnosis can lead to potentially devastating morbidity.No single investigation, including joint aspiration, is sufficiently reliable to diagnose conclusively paediatric bone and joint infection. Diagnosis should be based on a combination of c...
متن کاملRandomized trial of oral versus intravenous antibiotics in low-risk febrile neutropenic patients with lung cancer.
BACKGROUND Neutropenic fever is one of the most serious adverse effects of cancer chemotherapy. Neutropenia may cause a life-threatening bacterial infection. Therefore, febrile neutropenic inpatients are empirically treated with intravenous broad-spectrum antibiotics. Recently, several studies have suggested the presence of low-risk groups among febrile neutropenic patients. METHODS A prospec...
متن کاملResults of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis.
HYPOTHESIS For children with perforated appendicitis, the use of a prolonged course of intravenous (i.v.) antibiotics is equivalent to a short course of i.v. antibiotics followed by sequential conversion to oral (PO) antibiotics. DESIGN Prospective, randomized, clinical trial. SETTING Multicenter study in tertiary children's hospitals. PATIENTS Children (aged 5-18 years) with perforated a...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2019
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1710926